免疫原
Synthesized peptide derived from human ACTN4
特异性
This antibody detects endogenous levels of ACTN4 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation . Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA .
蛋白名称
Alpha-actinin-4 (F-actin cross-linking protein) (Non-muscle alpha-actinin 4)
其他名称
actinin 4;Actinin alpha 4;actinin4;ACTN 4;ACTN4;ACTN4_HUMAN;Alpha-actinin-4;DKFZp686K23158;F actin cross linking protein;F-actin cross-linking protein;Focal segmental glomerulosclerosis 1;FSGS 1;FSGS;FSGS1;Non muscle alpha actinin 4;Non-muscle alpha-actinin 4;Alpha-actinin-4 (F-actin cross-linking protein) (Non-muscle alpha-actinin 4)
细胞定位
Nucleus . Cytoplasm . Cell junction . Cytoplasm, cytoskeleton, stress fiber . Cytoplasm, perinuclear region . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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