免疫原
Synthesized peptide derived from human FBP17
特异性
This antibody detects endogenous levels of FBP17 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
基因名称（Gene Name）
FNBP1 FBP17 KIAA0554
蛋白名称
Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)
其他名称
FBP17;FNBP1;formin binding protein 1;Formin binding protein 17;hFBP17;KIAA554;FNBP1 FBP17 KIAA0554;Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
组织表达
Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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