免疫原
Synthesized peptide derived from human MCC
特异性
This antibody detects endogenous levels of MCC at Human
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation . Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity .
蛋白名称
Colorectal mutant cancer protein (Protein MCC)
其他名称
AIE 75 binding protein;AIE 75 binding protein protein;AIE-75-binding protein;AIEBP;MCC 2;MCC-2;MCC2;Mutated in colon cancer protein 2;USBP1_HUMAN;USH1C binding protein 1;USH1C-binding protein 1;Ushbp1;Usher syndrome 1C binding protein 1;Usher syndrome type 1C protein binding protein 1;Usher syndrome type-1C protein-binding protein 1;MCC;Colorectal mutant cancer protein (Protein MCC)
细胞定位
Cell membrane. Cell projection, lamellipodium. Nucleus . Cytoplasm . Colocalizes with actin at the leading edge of polarized cells.
组织表达
Expressed in a variety of tissues.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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