免疫原
Synthesized peptide derived from human iASPP
特异性
This antibody detects endogenous levels of iASPP at Human, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis .
基因名称(Gene Name)
PPP1R13L IASPP NKIP1 PPP1R13BL RAI
蛋白名称
RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)
其他名称
IASPP;inhibitor of apoptosis stimulating protein of p53;Inhibitor of ASPP protein;NFkB interacting protein 1;NKIP1;PPP1R13B-like protein;PPP1R13L;Protein iASPP;protein phosphatase 1 regulatory (inhibitor) subunit 13 like;RAI;RelA-associated inhibitor;PPP1R13L IASPP NKIP1 PPP1R13BL RAI;RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)
细胞定位
Cytoplasm . Nucleus . Predominantly cytoplasmic but also nuclear. .
组织表达
Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)