免疫原
Synthesized peptide derived from human METTL11A
特异性
This antibody detects endogenous levels of METTL11A at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation . Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
基因名称（Gene Name）
NTMT1 C9orf32 METTL11A NRMT AD-003
蛋白名称
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A)
其他名称
AD 003;AD-003;Alpha N-terminal protein methyltransferase 1A;C9orf32;EC:2.1.1.244;NTMT1 C9orf32 METTL11A NRMT AD-003;N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A)
细胞定位
Nucleus . Predominantly nuclear (PubMed:24090352).
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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