免疫原
Synthesized peptide derived from human PIR
特异性
This antibody detects endogenous levels of PIR at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
蛋白名称
Pirin (Probable quercetin 2;3-dioxygenase PIR) (Probable quercetinase)
其他名称
3-dioxygenase PIR;Iron binding nuclear protein;Pir;PIR_HUMAN;Pirin;Probable quercetin 2;Probable quercetinase;Pirin (Probable quercetin 2;3-dioxygenase PIR) (Probable quercetinase)
细胞定位
Nucleus . Cytoplasm . Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. .
组织表达
Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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