免疫原
Synthesized peptide derived from human CPNE1
特异性
This antibody detects endogenous levels of CPNE1 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes . Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner . Exhibits calcium-dependent phospholipid binding properties . Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner . May recruit target proteins to the cell membrane in a calcium-dependent manner . May function in membrane trafficking . Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit . Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL .
基因名称（Gene Name）
CPNE1 CPN1
其他名称
Copine 1;Copine I;Copine-1;Copine1;CopineI;COPN 1;COPN1;CPN 1;CPN1;CPNE 1;CPNE1;CPNE1_HUMAN;MGC1142;CPNE1 CPN1;Copine-1 (Copine I)
细胞定位
Nucleus . Cytoplasm . Cell membrane . Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). .
组织表达
Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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