免疫原
Synthesized peptide derived from human ARIH2
特异性
This antibody detects endogenous levels of ARIH2 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 . Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex . Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination . May play a role in myelopoiesis .
基因名称（Gene Name）
ARIH2 ARI2 TRIAD1 HT005
蛋白名称
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (Triad1 protein)
其他名称
HT5;all trans retinoic acid inducible RING finger;Ari 2;Ari-2;ARI2;ARI2_HUMAN;Ariadne 2;Ariadne 2 protein homolog;ariadne homolog 2 (Drosophila);ariadne homolog 2;Ariadne RBR E3 ubiquitin protein ligase 2;ARIH 2;Arih2;E3 ubiquitin protein ligase ARIH2;E3 ubiquitin-protein ligase ARIH2;protein ariadne 2 homolog;Protein ariadne-2 homolog;Triad 1;TRIAD1;Triad1 protein;UIP48;ARIH2 ARI2 TRIAD1 HT005;E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (Triad1 protein)
细胞定位
Nucleus . Cytoplasm .
组织表达
Widely expressed with higher expression in granulocytes.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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