WB

Synthesized peptide derived from human GBA

This antibody detects endogenous levels of GBA at Human, Mouse

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

WB 1:500-2000

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose . Plays a central role in the degradation of complex lipids and the turnover of cellular membranes . Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation . Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol . GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine) . Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide (Probable). Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol . Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers . Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside .

GBA GC GLUC

Glucosylceramidase (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase)

Acid beta glucosidase;Acid beta-glucosidase;Alglucerase;Beta glucocerebrosidase;BETA GLUCOSIDASE;ACID;Beta-glucocerebrosidase;betaGC;D glucosyl N acylsphingosine glucohydrolase;D-glucosyl-N-acylsphingosine glucohydrolase;EC 3.2.1.45;GBA;Gba protein;GBA1;GC;GCase;GCB;GLCM_HUMAN;GLUC;Glucocerebrosidase (alt.);Glucocerebrosidase;GLUCOCEREBROSIDASE PSEUDOGENE;Glucosidase beta;Glucosidase;beta;acid (includes glucosylceramidase);Glucosylceramidase;Imiglucerase;Lysosomal glucocerebrosidase;OTTHUMP33992;OTTHUMP33993;GBA GC GLUC;Glucosylceramidase (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase)

2629

P04062

14466

P17439

Lysosome membrane ; Peripheral membrane protein ; Lumenal side . Interaction with saposin-C promotes membrane association (PubMed:10781797). Targeting to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2 (PubMed:18022370). .

-15°C to -25°C/1 year(Do not lower than -25°C)