免疫原
Synthesized peptide derived from human LGI1
特异性
This antibody detects endogenous levels of LGI1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
基因名称（Gene Name）
LGI1 EPT UNQ775/PRO1569
蛋白名称
Leucine-rich glioma-inactivated protein 1 (Epitempin-1)
其他名称
EPT;ETL1;ADLTE;ADPAEF;ADPEAF;IB1099;EPITEMPIN;LGI1;LGI1 EPT UNQ775/PRO1569;Leucine-rich glioma-inactivated protein 1 (Epitempin-1)
细胞定位
Nucleus speckle . Nucleus, nucleoplasm . Nucleus envelope . Nucleus membrane ; Peripheral membrane protein . Colocalizes at the nuclear pore with DBP5 and NXF1. .
组织表达
Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at protein level).
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
联系我们
关注我们
您当前的位置： 
成功添加到购物车
