WB

Synthesized peptide derived from human XLF

This antibody detects endogenous levels of XLF at Human, Mouse,Rat

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

WB 1:500-2000

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination . Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends . Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends . May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary . Associates with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired . The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other . The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors . Binds DNA in a length-dependent manner .

NHEJ1 XLF

Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)

Cernunnos;FLJ1261;NHEJ 1;Nhej1;S. cerevisiae;homolog of;NHEJ1_HUMAN;Non homologous end joining factor 1;Non-homologous end-joining factor 1;Nonhomologous end joining factor 1;OTTHUMP164168;OTTHUMP26275;OTTHUMP26279;Protein cernunnos;XLF;XRCC4 like factor;XRCC4-like factor;NHEJ1 XLF;Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)

79840

Q9H9Q4

75570

Q3KNJ2

363251

Q6AYI4

Nucleus . Chromosome . Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer. .

Ubiquitously expressed.

-15°C to -25°C/1 year(Do not lower than -25°C)