免疫原
Synthesized peptide derived from human NFKBIZ
特异性
This antibody detects endogenous levels of NFKBIZ at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Involved in regulation of NF-kappa-B transcription factor complexes . Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation . Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer . Seems also to activate NF-kappa-B-mediated transcription . In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters . Promotes transcription of LCN2 and DEFB4 . Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).
基因名称（Gene Name）
NFKBIZ IKBZ INAP MAIL
蛋白名称
NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL)
其他名称
FLJ3225;FLJ34463;I-kappa-B-zeta;Ikappa B zeta;IkappaB zeta;IkappaBzeta;IkB-zeta;IKBZ;IKBZ_HUMAN;IKBzeta;IL-1 inducible nuclear ankyrin-repeat protein;INAP;MAIL;MAIL protein;Molecule possessing ankyrin repeats induced by lipopolysaccharide;NF-kappa-B inhibitor zeta;NFKBIZ;Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta;NFKBIZ IKBZ INAP MAIL;NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL)
细胞定位
Nucleus . Aggregated in dot-like structures (PubMed:16513645). Colocalizes with NCOR2 (PubMed:16513645). .
组织表达
Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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