免疫原
Synthesized peptide derived from human DHCR24
特异性
This antibody detects endogenous levels of DHCR24 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis . In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress . Also protects against amyloid-beta peptide-induced apoptosis .
基因名称（Gene Name）
DHCR24 KIAA0018
蛋白名称
Delta(24)-sterol reductase (24-dehydrocholesterol reductase) (3-beta-hydroxysterol delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)
其他名称
DHC24;24-dehydrocholesterol reductase;3-beta-hydroxysterol Delta-24-reductase;Delta(24)-sterol reductase;EC:1.3.1.72;DHCR24 KIAA0018;Delta(24)-sterol reductase (24-dehydrocholesterol reductase) (3-beta-hydroxysterol delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus membrane ; Single-pass membrane protein .
组织表达
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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