免疫原
The antiserum was produced against synthesized peptide derived from human IgA. AA range:227-276
特异性
IgA Polyclonal Antibody detects endogenous levels of IgA protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
disease:A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.,function:Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.,PTM:3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.,similarity:Contains 3 Ig-like (immunoglobulin-like) domains.,subunit:Monomeric or polymeric.,
功能
Disease:A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.,Function:Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.,PTM:3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.,similarity:Contains 3 Ig-like (immunoglobulin-like) domains.,subunit:Monomeric or polymeric.,
基因名称（Gene Name）
IGHA1/IGHA2
蛋白名称
Ig alpha-1 chain C region/Ig alpha-2 chain C region
其他名称
FLJ14473;FLJ3565;FLJ355;FLJ3642;FLJ39698;FLJ41;FLJ41548;FLJ41552;FLJ41789;FLJ43248;FLJ43594;FLJ44293;FLJ4628;FLJ46621;FLJ46724;FLJ46811;FLJ46824;FLJ917;Ig alpha 1 chain C region;IgA1;IGHA1;immunoglobulin heavy constant alpha 1;MGC12857;A2m marker;Ig alpha 2 chain C region;IgA constant heavy chain 2;IGHA 2;IGHA2;IGHA2 protein;Immunoglobulin A2;Immunoglobulin Am2;immunoglobulin heavy constant alpha 2 (A2m marker);Immunoglobulin heavy constant alpha 2;IGHA1/IGHA2;Ig alpha-1 chain C region/Ig alpha-2 chain C region;Ig alpha-1 chain C region;Ig alpha-2 chain C region
细胞定位
Secreted . Cell membrane .
组织表达
Bile,Colon,Mammary gland,Stomach mucosa,
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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