免疫原
Synthesized peptide derived from human BLOC1S1
特异性
This antibody detects endogenous levels of BLOC1S1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension . As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor . ; May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
基因名称（Gene Name）
BLOC1S1 BLOS1 GCN5L1 RT14
蛋白名称
Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) (GCN5-like protein 1) (Protein RT14)
其他名称
Biogenesis of lysosome-related organelles complex 1 subunit 1;BLOC 1 subunit 1;BLOC-1 subunit 1;BLOS1;GCN5 like protein 1;BLOC1S1 BLOS1 GCN5L1 RT14;Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) (GCN5-like protein 1) (Protein RT14)
细胞定位
Mitochondrion intermembrane space . Mitochondrion matrix . Cytoplasm, cytosol . Lysosome membrane .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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