免疫原
Synthesized peptide derived from human TRIM39
特异性
This antibody detects endogenous levels of TRIM39 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
[Isoform 1]: E3 ubiquitin-protein ligase . May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 . Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . ; [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner .
基因名称（Gene Name）
TRIM39 RNF23 TFP
蛋白名称
E3 ubiquitin-protein ligase TRIM39 (RING finger protein 23) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)
其他名称
TFP;RNF23;TRIM39B;TRIM39;TRIM39 RNF23 TFP;E3 ubiquitin-protein ligase TRIM39 (RING finger protein 23) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)
细胞定位
[Isoform 1]: Cytoplasm, cytosol . Mitochondrion . Nucleus . Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. .; [Isoform 2]: Nucleus . Colocalizes with CDKN1A in the nucleus. .
组织表达
Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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