免疫原
Synthesized peptide derived from human PLEKHF1
特异性
This antibody detects endogenous levels of PLEKHF1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
基因名称（Gene Name）
PLEKHF1 APPD LAPF ZFYVE15
蛋白名称
Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15)
其他名称
Apoptosis inducing protein;Apoptosis-inducing protein;APPD;LAPF;Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains;PLEKHF1 APPD LAPF ZFYVE15;Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15)
细胞定位
Nucleus . Cytoplasm, perinuclear region . Lysosome . Translocates to lysosome during apoptosis.
组织表达
Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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