免疫原
Synthesized peptide derived from human ERO1L
特异性
This antibody detects endogenous levels of ERO1L at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
基因名称（Gene Name）
ERO1L UNQ434/PRO865
蛋白名称
ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (Endoplasmic oxidoreductin-1-like protein) (Oxidoreductin-1-L-alpha)
其他名称
Endoplasmic oxidoreductin 1 like protein;Endoplasmic oxidoreductin-1-like protein;Endoplasmic reticulum oxidoreductase 1 alpha;Endoplasmic reticulum oxidoreductin 1-like;ERO1 alpha;ERO1 L;ERO1 Lalpha;ERO1 like protein alpha;ERO1-alpha;ERO1-L;ERO1-L-alpha;ERO1-like (S. cerevisiae);ERO1-like alpha;ERO1-like protein alpha;ERO1-like;S. cerevisiae;homolog of;alpha;ERO1A;ERO1A_HUMAN;ERO1L;ERO1LA;Oxidoreductin 1 Lalpha;Oxidoreductin-1-L-alpha;PRO865;UNQ434;ERO1L UNQ434/PRO865;ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (Endoplasmic oxidoreductin-1-like protein) (Oxidoreductin-1-L-alpha)
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side . The association with ERP44 is essential for its retention in the endoplasmic reticulum.
组织表达
Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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