免疫原
Synthesized peptide derived from human NGEF
特异性
This antibody detects endogenous levels of NGEF at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
蛋白名称
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
其他名称
EPHEXIN;ARHGEF27;NGEF;Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
细胞定位
Cytoplasm . Membrane . Cell projection, growth cone . Associated with membranes. Localizes to axonal growth cones (By similarity). .
组织表达
Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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