免疫原
Synthesized peptide derived from human SLC7A6
特异性
This antibody detects endogenous levels of SLC7A6 at Human, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
基因名称(Gene Name)
SLC7A6 KIAA0245
蛋白名称
Y+L amino acid transporter 2 (Cationic amino acid transporter;y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
其他名称
KIAA0245;LAT 2;LAT3;SLC7A6;Y+L amino acid transporter 2;y+LAT 2;Y+LAT2;SLC7A6 KIAA0245;Y+L amino acid transporter 2 (Cationic amino acid transporter;y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
细胞定位
Basolateral cell membrane ; Multi-pass membrane protein .
组织表达
Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)