免疫原
Synthesized peptide derived from human Geminin
特异性
This antibody detects endogenous levels of Geminin at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) . It is degraded during the mitotic phase of the cell cycle . Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle . Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing . Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control .
其他名称
GMNN;MGORS6;Gem;2E3A2;Geminin
细胞定位
Cytoplasm . Nucleus . Mainly cytoplasmic but can be relocalized to the nucleus. .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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