免疫原
Synthesized peptide derived from human RNase T2
特异性
This antibody detects endogenous levels of RNase T2 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 . Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides . In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 . Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria . Participates as well in degradation of mitochondrion-associated cytosolic rRNAs .
基因名称（Gene Name）
RNASET2 RNASE6PL
蛋白名称
Ribonuclease T2 (Ribonuclease 6)
其他名称
RNase T2;bA514O12.3;EC:4.6.1.19;Ribonuclease 6;Ribonuclease T2;RNASET2 RNASE6PL;Ribonuclease T2 (Ribonuclease 6)
细胞定位
Secreted . Lysosome lumen . Endoplasmic reticulum lumen . Mitochondrion intermembrane space . Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction. .
组织表达
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
联系我们
关注我们
您当前的位置： 
成功添加到购物车
