免疫原
Synthesized peptide derived from human WWP2. AA range:25-125
特异性
This antibody detects endogenous levels of WWP2 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
蛋白名称
NEDD4-like E3 ubiquitin-protein ligase WWP2 (Atrophin-1-interacting protein 2) (AIP2) (WW domain-containing protein 2)
其他名称
WWP2;NEDD4-like E3 ubiquitin-protein ligase WWP2 (Atrophin-1-interacting protein 2) (AIP2) (WW domain-containing protein 2)
组织表达
Detected in heart , throughout the brain , placenta , lung , liver , muscle , kidney and pancreas. Also detected in spleen and peripheral blood leukocytes.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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