免疫原
Synthesized peptide derived from human FBXO2
特异性
This antibody detects endogenous levels of FBXO2 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).
基因名称（Gene Name）
FBXO2 FBX2
蛋白名称
F-box only protein 2
其他名称
FBG1;F-box only protein 2;Fbs1;FBX2;NFB42;FBXO2 FBX2
细胞定位
Cytoplasm . Microsome membrane ; Peripheral membrane protein ; Cytoplasmic side .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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