免疫原
Synthesized peptide derived from human MUC20
特异性
This antibody detects endogenous levels of MUC20 at Human, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
基因名称(Gene Name)
MUC20 KIAA1359 UNQ2782/PRO7170
其他名称
KIAA1359;MUC 20;MUC20;Mucin 20;MUC20 KIAA1359 UNQ2782/PRO7170;Mucin-20 (MUC-20)
细胞定位
Secreted . Apical cell membrane . Basolateral cell membrane . Cell projection, microvillus membrane .
组织表达
Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)