免疫原
Synthesized peptide derived from human TEAD4
特异性
This antibody detects endogenous levels of TEAD4 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
基因名称（Gene Name）
TEAD4 RTEF1 TCF13L1 TEF3
蛋白名称
Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)
其他名称
EFTR 2;hRTEF 1B;RTEF1;TCF13L1;TEA domain family member 4;TEAD4;TEAD4 RTEF1 TCF13L1 TEF3;Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)
组织表达
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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