免疫原
Synthesized peptide derived from human PHD1
特异性
This antibody detects endogenous levels of PHD1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A . Target proteins are preferentially recognized via a LXXLAP motif . Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins . Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A . Also hydroxylates HIF2A . Has a preference for the CODD site for both HIF1A and HIF2A . Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex . Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, a
基因名称（Gene Name）
EGLN2 EIT6
蛋白名称
Egl nine homolog 2 (EC 1.14.11.29) (Estrogen-induced tag 6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing p
其他名称
DKFZp434E26;EGL nine (C.elegans) homolog 2;Egl nine homolog 2 (C. elegans);Egl nine homolog 2;EGLN 2;EGLN2;EGLN2_HUMAN;EIT 6;EIT6;Estrogen-induced tag 6;HIF P4H 1;HIF PH1;HIF prolyl hydroxylase 1;HIF-PH1;HIF-prolyl hydroxylase 1;HIFPH 1;HIFPH1;HPH 3;HPH-1;HPH-3;HPH3;Hypoxia inducible factor prolyl hydroxylase 1;Hypoxia-inducible factor prolyl hydroxylase 1;P4H1;PHD 1;PhD1;prolyl hydroxylase domain containing protein 1;Prolyl hydroxylase domain-containing protein 1;EGLN2 EIT6;Egl nine homolog 2 (EC 1.14.11.29) (Estrogen-induced tag 6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing p
组织表达
Expressed in adult and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in adult brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and cancerous mammary, ovarian and prostate epitheliu
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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