免疫原
Synthesized peptide derived from human CK14 AA range: 400-472
特异性
The antibody can specifically recognize human CK14 protein. In
immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the
antibody specifically labels the basal cell of squamous ep
组成（Formulation）
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
稀释比例
IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
纯化工艺（Immunogen）
Protein G
背景（Background）
This gene encodes a member of the keratin family, the most diverse group of
intermediate filaments. This gene product, a type I keratin, is usually found as a
heterotetramer with two keratin 5 molecules, a type II keratin. Together they form
the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are
associated with epidermolysis bullosa simplex. At least one pseudogene has
been identified at 17p12-p11. [provided by RefSeq, Jul 2008],
功能
disease:Defects in KRT14 are a cause of epidermolysis bullosa simplex DowlingMeara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal
epidermolysis bullosa characterized by generalized herpetiform blistering, milia
formation, dystrophic nails, and mucous membrane involvement.,disease:Defects
in KRT14 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS)
[MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa
characterized by generalized skin blistering. The phenotype is not fundamentally
distinct from the Dowling-Meara type, althought it is less severe.,disease:Defects
in KRT14 are a cause of epidermolysis bullosa simplex Weber-Cockayne type
(WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis
bullosa characterized by blistering limited to palmar and plantar areas of the
skin.,disease:Defects in KRT14 are the cause of derma
其他名称
KRT14;CK 14;CK14;CK-14;Cytokeratin;Keratin;Cytokeratin 14
Fields
>>Estrogen signaling pathway;>>Staphylococcus aureus infection
细胞定位
Cytoplasmic, Membranous
组织表达
Expressed in the corneal epithelium (at protein level) (PubMed:26758872).
Detected in the basal layer, lowered within the more apically located layers
specifically in the stratum spinosum, stratum granulosum but is not detected in
stratum corneum. Strongly expressed in the outer root sheath of anagen follicles
but not in the germinative matrix, inner root sheath or hair (PubMed:9457912).
Found in keratinocytes surrounding the club hair during telogen
(PubMed:9457912)
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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