免疫原
Synthesized peptide derived from human Arginase-1 AA range: 200-322
特异性
The antibody can specifically recognize human Arginase-1 protein. In western
blotting of HepG2 cell lysate, the antibody can label a 35 kDa band corresponding
to Arginase-1.
组成（Formulation）
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
稀释比例
IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
纯化工艺（Immunogen）
Protein G
背景（Background）
Arginase-1 is a key enzyme in the urea cycle, which can catalyze the
decomposition of arginine into ornithine and urea. Highly specific expression in
liver tissue, but not in bile duct epithelial cells, hepatic sinusoidal endothelial cells,
Kupffer cells and vascular endothelial cells.
功能
catalytic activity:L-arginine + H(2)O = L-ornithine + urea.,cofactor:Binds 2
manganese ions per subunit.,disease:Defects in ARG1 are the cause of
argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia.
Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is
elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia
occurs. Clinical manifestations include developmental delay, seizures, mental
retardation, hypotonia, ataxia, progressive spastic quadriplegia.,induction:By
arginine or homoarginine.,online information:Arginase entry,pathway:Nitrogen
metabolism; urea cycle; L-ornithine and urea from L-arginine: step
1/1.,similarity:Belongs to the arginase family.,subunit:Homotrimer.,
蛋白名称
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
其他名称
ARG1;Arginase 1;liver Arginase;ARG 1;Arg-1;Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
Fields
>>Arginine biosynthesis;>>Arginine and proline metabolism;>>Metabolic
pathways;>>Biosynthesis of amino acids;>>Amoebiasis
细胞定位
Nuclear, Cytoplasmic
组织表达
Expression :Within the immune system initially reported to be selectively expressed in
granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also
detected in macrophages mycobacterial granulomas (PubMed:23749634).
Expressed in group2 innate lymphoid cells (ILC2s) during lung disease
(PubMed:27043409).
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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