免疫原
Synthesized peptide derived from human SLC19A1
特异性
This antibody detects endogenous levels of SLC19A1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides . Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate . Also able to mediate the import of antifolate drug methotrexate . Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP . Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates . 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity .
基因名称（Gene Name）
SLC19A1 FLOT1 RFC1
蛋白名称
Folate transporter 1 (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (Solute carrier family 19 member 1)
其他名称
CHMD;FLOT1;Folate transporter 1;FOLT;IFC 1;IFC1;Intestinal folate carrier 1;Placental folate transporter;Reduced folate carrier protein;REFC;RFC;RFC1;SLC19A1;SLC19A1 FLOT1 RFC1;Folate transporter 1 (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (Solute carrier family 19 member 1)
细胞定位
Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .
组织表达
Placenta, liver, and to a much smaller extent, in lung.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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