免疫原
Synthesized peptide derived from human SIRT5
特异性
This antibody detects endogenous levels of SIRT5 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins . Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting . Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species . Activates SHMT2 by mediating its desuccinylation . Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
基因名称（Gene Name）
SIRT5 SIR2L5
蛋白名称
NAD-dependent protein deacylase sirtuin-5;mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
其他名称
EC:2.3.1.-;NAD-dependent protein deacylase sirtuin-5;mitochondrial;Regulatory protein SIR2 homolog 5;SIR2L5;SIR2-like protein 5;SIRT5;SIRT5 SIR2L5;mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
细胞定位
Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.; [Isoform 1]: Cytoplasm . Mitochondrion .; [Isoform 2]: Mitochondrion .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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