免疫原
Synthesized peptide derived from human CD3, CD3E AA range: 1-100
特异性
The antibody can specifically recognize human CD3e protein, and shows no reaction with CD3d or CD3g. In western blotting of Jurkat cell lysate, the antibody can label a 23 kDa band corresponding to CD
组成（Formulation）
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
稀释比例
IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
纯化工艺（Immunogen）
Protein G
背景（Background）
CD3 protein contains ε、γ、δ and ζ four subunits, including extracellular, transmembrane and intracellular domains. CD3 is a T cell marker, which is not expressed by B cells. CD3 complex mediates TCR antigen recognition, leading to T cell proliferation and cytokine release. It is mainly used for the diagnosis of T-cell lymphoma, with high specificity but low sensitivity. In order to improve the accuracy of diagnosis, it is usually combined with CD45RO in clinical application.
功能
function:The CD3 complex mediates signal transduction.,online information:CD3E mutation db,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.,
其他名称
CD3E;CD3 Epsilon;CD3-epsilon;T3E;T-cell surface antigen T3/Leu-4 epsilon chain;CD3E T3E;CD3;4930549J05Rik;A430104F18Rik;AW552088;Cd247;CD247 antigen;zeta subunit;CD247 molecule;CD3 antigen;delta subunit;CD3 delta;CD3 eta;CD3 gamma;CD3 molecule delta polypeptide;CD3 molecule;epsilon polypeptide;gamma polypeptide;CD3 zeta;CD3-DELTA;CD3d;CD3D antigen delta polypeptide;CD3d antigen;delta polypeptide (TiT3 complex);CD3d molecule delta;CD3d molecule delta CD3 TCR complex;CD3d molecule;delta (CD3-TCR complex);CD3D_HUMAN;CD3e antigen;CD3E antigen epsilon polypeptide;epsilon polypeptide (TiT3 complex);CD3e molecule epsilon;CD3e molecule epsilon CD3 TCR complex;CD3e molecule;epsilon (CD3-TCR complex);CD3epsilon;CD3G;CD3g antigen;CD3G antigen gamma polypeptide;gamma polypeptide (TiT3 complex);CD3g molecule gamma;CD3g molecule gamma CD3 TCR complex;CD3g molecule;gamma (CD3-TCR complex);CD3H;CD3Q;CD3Z;CD3zeta;Ctg3;FLJ17620;FLJ17664;FLJ18683;FLJ79544;FLJ94613;IMD19;Leu-4;MGC138597;OKT3;delta chain;OTTHUMP0
Fields
>>Hematopoietic cell lineage;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Chagas disease;>>Measles;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Primary immunodeficiency
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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