免疫原
Synthesized peptide derived from human PFKFB2 (Phospho Ser466)
特异性
This antibody detects endogenous levels of PFKFB2 (Phospho Ser466) Rabbit pAb at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 IHC 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2(PFKFB2) Homo sapiens The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in the activation of the kinase activity.,function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Heart.,
蛋白名称
6-phosphofructo-2-kinase/fructose-2;6-bisphosphatase 2 (6PF-2-K/Fru-2;6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2;6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105);Fructose-
其他名称
6 phosphofructo 2 kinase/ fructose 2;6 bisphosphatase;6 phosphofructo 2 kinase/fructose 2;6 biphosphatase 3;6-bisphosphatase;6-P2ase 3;6-P2ASE brain/placenta-type isozyme;6PF 2 K/Fru 2;6 P2ASE brain/placenta type isozyme;6PF 2-K/Fru 2;6 P2ase 3;6PF-2-K/Fru-2;F263_HUMAN;fructose 6 phosphate;2 kinase/fructose 2;Fructose-2;Inducible 6 phosphofructo 2 kinase/fructose 2;iPFK 2;iPFK-2;IPFK2;PFK/FBPase 3;PFK2;PFKFB3;Renal carcinoma antigen NY REN 56;Renal carcinoma antigen NY-REN-56;uPFK 2;PFK-2 car;PFKFB2;6-phosphofructo-2-kinase/fructose-2;6-bisphosphatase 2 (6PF-2-K/Fru-2;6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2;6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105);Fructose-;6-bisphosphatase (EC 3.1.3.46)]
Fields
>>Fructose and mannose metabolism;>>Metabolic pathways;>>AMPK signaling pathway;>>Thyroid hormone signaling pathway
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