免疫原
The antiserum was produced against synthesized peptide derived from human CD18/ITGB2. AA range:720-769
特异性
Integrin β2 Polyclonal Antibody detects endogenous levels of Integrin β2 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
功能
disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on S
其他名称
95 subunit beta;Beta 2 (antigen CD18 (p95);CD 18;CD18;Cell surface adhesion glycoprotein LFA 1/CR3/P15;959 beta subunit precursor);Cell surface adhesion glycoproteins LFA 1/CR3/p15;Cell surface adhesion glycoproteins LFA-1/CR3/p15;Complement component 3 receptor 3 and 4 subunit;Complement receptor C3 beta subunit;Complement receptor C3 subunit beta;Integrin beta 2;Integrin beta chain beta 2;Integrin beta-2 (ITGB2);Integrin beta-2;Integrin;beta 2 (complement component 3 receptor 3 and 4 subunit);ITB2_HUMAN;ITGB2;LAD;LCAMB;Leukocyte associated antigens CD18/11A;CD18/11B;CD18/11C;Leukocyte cell adhesion molecule CD18;LFA 1;LFA1;Lymphocyte function associated antigen 1 (LFA1);Lymphocyte function associated antigen 1;MAC 1;MAC1;Macrophage antigen 1 (mac1) beta;MF17;MFI7;OTTHUMP115278;OTTHUMP115279;OTTHUMP11528;OTTHUMP115281;OTTHUMP115282;Integrin β2;Cell surface adhesion glycoproteins LFA-1/CR3/p150;CD antigen CD18
Fields
>>Rap1 signaling pathway;>>Phagosome;>>Hippo signaling pathway;>>Cell adhesion molecules;>>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Natural killer cell mediated cytotoxicity;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Pertussis;>>Legionellosis;>>Leishmaniasis;>>Malaria;>>Amoebiasis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Human T-cell leukemia virus 1 infection;>>Rheumatoid arthritis;>>Viral myocarditis
细胞定位
Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .
组织表达
Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).
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