免疫原
The antiserum was produced against synthesized peptide derived from human AF4. AA range:1-50
特异性
AF-4 Polyclonal Antibody detects endogenous levels of AF-4 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000 IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu
功能
disease:A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein.,similarity:Belongs to the AF4 family.,
蛋白名称
AF4/FMR2 family member 1
其他名称
AF4/FMR2 family member 4;AF5Q31;Alf4;ALL1 fused gene from chromosome 5q31;HSPC92;Laf4;Lymphoid nuclear protein related to AF4 like;Major CDK9 elongation factor associated protein;MCEF;MGC17469;RP23-226J16.7;AF-4;AFF1;AF4/FMR2 family member 1;AF4;FEL;MLLT2;PBM1;ALL1-fused gene from chromosome 4 protein;Protein AF-4;Protein FEL;Proto-oncogene AF4
Fields
>>Transcriptional misregulation in cancer
组织表达
Epithelium,PCR rescued clones,Placenta,
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