免疫原
The antiserum was produced against synthesized peptide derived from human GABRG1. AA range:11-60
特异性
GABAA Rγ1 Polyclonal Antibody detects endogenous levels of GABAA Rγ1 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008],
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,miscellaneous:This subunit carries the benzodiazepine binding site.,online information:Forbidden fruit - Issue 56 of March 2005,PTM:May be palmitoylated.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
蛋白名称
Gamma-aminobutyric acid receptor subunit gamma-1
其他名称
ECA4;EIEE19;EJM;EJM5;Gaba receptor alpha 1 polypeptide;GABA(A) receptor;GABA(A) receptor subunit alpha 1;GABA(A) receptor subunit alpha-1;alpha 1;GABRA 1;GABRA1;Gamma aminobutyric acid (GABA) A receptor alpha 1;Gamma aminobutyric acid A receptor alpha 1;Gamma aminobutyric acid receptor subunit alpha 1;Gamma aminobutyric acid type A receptor alpha1 subunit;Gamma-aminobutyric acid receptor subunit alpha-1;GBRA1_HUMAN;GABAA Rγ1;GABRG1;Gamma-aminobutyric acid receptor subunit gamma-1;GABA(A) receptor subunit gamma-1
Fields
>>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction
细胞定位
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
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