免疫原
Synthetic Peptide of L-type Ca++ CP γ4 AA range: 120-200
特异性
The antibody detects endogenous L-type Ca++ CP γ4 protein.
组成（Formulation）
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
稀释比例
WB: 1:1000-2000 IHC: 1:200-500. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
calcium voltage-gated channel auxiliary subunit gamma 4(CACNG4) Homo sapiens The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010],
功能
function:Thought to stabilize the calcium channel in an inactivated (closed) state.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.,
蛋白名称
Voltage-dependent calcium channel gamma-4 subunit
其他名称
4F2 LC;4F2 light chain;4F2LC;CD98;CD98 light chain;CD98LC;D16S469E;DC49;E16;hLAT1;Integral membrane protein E16;L type amino acid transporter;L type amino acid transporter 1;L-type amino acid transporter 1;Large neutral amino acids transporter 1;Large neutral amino acids transporter;Large neutral amino acids transporter small subunit 1;LAT1;LAT1_HUMAN;Membrane protein E16;MPE16;Slc7a5;Sodium independent neutral amino acid transporter;Sodium independent neutral amino acid transporter LAT1;Solute carrier family 7 (cationic amino acid transporter y+ system) member 5;Solute carrier family 7 member 5;TA1;Tumor associated protein 1;y+ system cationic amino acid transporter;L-type Ca++ CP γ4;CACNG4;Voltage-dependent calcium channel gamma-4 subunit;Neuronal voltage-gated calcium channel gamma-4 subunit;Transmembrane AMPAR regulatory protein gamma-4;TARP gamma-4
Fields
>>MAPK signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Oxytocin signaling pathway;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
细胞定位
Cell membrane ; Multi-pass membrane protein .
组织表达
Detected in heart left ventricle.
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