WB

Purified recombinant human EP-CAM (N-terminus) protein fragments expressed in E.coli.

EP-CAM Monoclonal Antibody detects endogenous levels of EP-CAM protein.

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.

Affinity purification

1 mg/ml

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008],

EPCAM

Epithelial cell adhesion molecule

Ep-CAM

17 1A;323/A3;Adenocarcinoma associated antigen;Adenocarcinoma-associated antigen;Antigen identified by monoclonal antibody AUA1;AUA1;CD326;CD326 antigen;Cell surface glycoprotein Trop 1;Cell surface glycoprotein Trop 2;Cell surface glycoprotein Trop-1;CO 17A;CO17 1A;CO17A;DIAR5;EGP 2;EGP;EGP2;EGP314;EGP4;Ep CAM;Ep-CAM;EPCAM;EPCAM_HUMAN;EpCAM1;Epithelial cell adhesion molecule;Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD);Epithelial cell surface antigen;Epithelial cellular adhesion molecule;Epithelial glycoprotein 1;Epithelial glycoprotein 314;Epithelial glycoprotein;ESA;GA733 1;GA733 2;GA733-2;gastrointestinal tumor-associated antigen 2;35-KD glycoprotein;gp4;hEGP 2;hEGP314;HNPCC8;Human epithelial glycoprotein 2;KS 1/4 antigen;KS1/4;KSA;Ly74;Lymphocyte antigen 74;M1S 1;M1S2;M4S1;Major gastrointestinal tumor associated protein GA733 2;Major gastrointestinal tumor-associated protein GA733-2;mEGP314;Membrane component chromosome 4 surface marker (35kD glycoprotein);Membrane component;chromosome 4;surface marker 1;surface marker;MIC18;MK 1;Protein 289A;TACD1;TACSTD1;TROP1;Tumor associated calcium signal transducer 1;Tumor associated calcium signal transducer 2 precursor;Tumor-associated calcium signal transducer 1;Epithelial gly

4072

P16422

17075

Q99JW5

Lateral cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Colocalizes with CLDN7 at the lateral cell membrane and tight junction. .

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.

-20°C/1 year