免疫原
The antiserum was produced against synthesized peptide derived from human GNAT2. AA range:1-50
特异性
Gα t2 Polyclonal Antibody detects endogenous levels of Gα t2 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008],
功能
disease:Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4) [MIM:139340]. Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination.,function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.,tissue specificity:Retinal rod outer segment.,
蛋白名称
Guanine nucleotide-binding protein G(t) subunit alpha-2
其他名称
Glutathione S alkyltransferase A1;Glutathione S aryltransferase A1;Glutathione S transferase 2;Glutathione S transferase A1;Glutathione S transferase alpha 1;Glutathione S transferase Ha subunit 1;Glutathione S-transferase A1;GST class-alpha member 1;GST epsilon;GST HA subunit 1;GST;class alpha;1;GST-epsilon;GST2;GSTA1 1;GSTA1;GSTA1-1;GSTA1_HUMAN;GTH1;HA subunit 1;MGC131939;OTTHUMP16611;S (hydroxyalkyl)glutathione lyase A1;Gα t2;GNAT2;Guanine nucleotide-binding protein G(t) subunit alpha-2;GNATC;Transducin alpha-2 chain
Fields
>>Phototransduction
细胞定位
Cell projection, cilium, photoreceptor outer segment . Photoreceptor inner segment . Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. .
组织表达
Retinal rod outer segment.
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