免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human IL36RN. AA range:1-50
特异性
IL-1F5 Polyclonal Antibody detects endogenous levels of IL-1F5 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008],
功能
function:Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.,induction:By phorbol ester (PMA) and lipopolysaccharide (LPS) treatment in macrophage cell line.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,tissue specificity:Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.,
蛋白名称
Interleukin-36 receptor antagonist protein
其他名称
AI413231;Family of interleukin 1 delta;FIL1;FIL1 delta;FIL1(DELTA);FIL1D;Fil1delta;I36RA_HUMAN;IL 1 delta;IL 1 related protein 3;IL 1F5 (IL 1HY1;IL 1RP3;IL 1L1;IL 1 delta);Il 1h3;IL 1HY1;IL 1ra homolog;IL1F5 (Canonical product IL 1F5a);IL-1 delta;IL-1-related protein 3;IL-1F5;IL-1HY1;IL-1L1;IL-1ra homolog 1;IL-1RP3;IL1F5;IL1HY1;IL1L1;IL1RP3;IL36RA;IL36RN;Interleukin 1 delta;Interleukin 1 family member 5 (delta);Interleukin 1 family member 5;Interleukin 1 HY1;Interleukin 1 like protein 1;Interleukin 1 receptor antagonist homolog 1;Interleukin 36 receptor antagonist;Interleukin-1 delta;Interleukin-1 family member 5;Interleukin-1 HY1;Interleukin-1 receptor antagonist homolog 1;Interleukin-1-like protein 1;Interleukin-36 receptor antagonist protein;MGC2984;PSORP;RP23-176J12.6
Fields
>>Cytokine-cytokine receptor interaction
细胞定位
Cytoplasm . Secreted . The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. .
组织表达
Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
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