免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human LEFTY1/LEFTY2. AA range:301-350
特异性
Lefty Polyclonal Antibody detects endogenous levels of Lefty protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016],
功能
function:Required for left-right axis determination as a regulator of LEFTY2 and NODAL.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,similarity:Belongs to the TGF-beta family.,
基因名称（Gene Name）
LEFTY1/LEFTY2
蛋白名称
Left-right determination factor 1/Left-right determination factor 2
其他名称
AI4552;Ebaf;Left right determination factor 1;Left right determination factor;Left right determination factor B;left-right determination factor;LEFT-RIGHT DETERMINATION FACTOR 1;LEFTY1;left-right determination;factor B;LEFTY B;LEFTB;LEFTY 1;Lefty;lefty-1;MOUSE;HOMOLOG OF;LEFTYB;OTTHUMP35572;Protein lefty-1;Protein lefty-B;RGD1561867;Stimulated by retinoic acid gene 3 protein;STRA3;TGF beta 4;TGF-beta-4;Tgfb4;Transforming growth factor beta 4;Transforming growth factor beta-4;LEFTY1/LEFTY2;Left-right determination factor 1/Left-right determination factor 2;Left-right determination factor B;LEFTY2;LEFTA;LEFTYA;PSEC0024;Left-right determination factor 2;Endometrial bleeding-associated factor;Left-right determination factor A;Protein lefty-2;Protein lefty-A
Fields
>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells
组织表达
Colon,Pancreas,Spleen,Teratocarcinoma,
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