免疫原
The antiserum was produced against synthesized peptide derived from human GROalpha. AA range:39-88
特异性
GROα Polyclonal Antibody detects endogenous levels of GROα protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014],
功能
function:Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.,online information:CXCL1 entry,PTM:N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,
蛋白名称
Growth-regulated alpha protein
其他名称
C-X-C motif chemokine 1;Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity;alpha);chemokine (C-X-C motif) ligand 1;CINC-1;CXCL1;Cytokine-induced neutrophil chemoattractant 1;Fibroblast secretory protein;Fsp;Gro 1;Gro A;Gro;GRO protein;alpha;GRO-alpha(1-73);GRO-alpha(6-73);Gro1;GRO1 oncogene (melanoma growth stimulating activity;GRO1 oncogene (melanoma growth-stimulating activity);Gro1 oncogene;GROa;GROA_HUMAN;Growth-regulated alpha protein;KC;KC chemokine;mouse;homolog of;melanoma growth stimulatory activity alpha;Melanoma growth stimulatory activity;MGSA alpha;MGSA;MGSA-a;N51;NAP-3;NAP3;Neutrophil-activating protein 3;Platelet-derived growth factor-inducible protein KC;Scyb 1;Scyb1;Secretory protein N51;Small inducible cytokine subfamily B;member 1;GROα
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NF-kappa B signaling pathway;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Alcoholic liver disease;>>Epithelial cell signaling in Helicobacter pylori infection;>>Legionellosis;>>Amoebiasis;>>Kaposi sarcoma-associated herpesvirus infection;>>Rheumatoid arthritis;>>Lipid and atherosclerosis
组织表达
Blood,Ovary,Peripheral blood monocyte,Placenta,Skin,
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