免疫原
The antiserum was produced against synthesized peptide derived from human PKD1/2/3/PKC mu. AA range:706-755
特异性
PKD1/2/3 Polyclonal Antibody detects endogenous levels of PKD1/2/3 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by diacylglycerol and phorbol esters.,function:Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase involved in resistance to oxidative stress.,PTM:Phosphorylation of Ser-738 and/or Ser-742 in activated PKD is mediated by transphosphorylation (By similarity). Phosphorylation of Tyr-463 mediated by the Src/Abl pathway in response to oxidative stress activates the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with Src.,
蛋白名称
Serine/threonine-protein kinase D1
其他名称
DKFZp586E82;HSPC187;KPCD2_HUMAN;nPKC D2;nPKC-D2;PKD2;PRKD 2;Prkd2;Protein kinase D2;Serine/threonine protein kinase D2;Serine/threonine-protein kinase D2;KPCD1_HUMAN;nPKC D1;nPKC mu;nPKC-D1;nPKC-mu;nPKCD1;nPKCmu;PKC;PKC MU;PKCM;PKCmu;PKD 1;PKD;PKD1;PRKCM;PRKD 1;Prkd1;Protein kinase C mu;Protein kinase C mu type;Protein kinase D;Protein kinase D1;Serine/threonine protein kinase D1;Serine/threonine-protein kinase D1;EPK 2;EPK2;KPCD3_HUMAN;nPKC nu;nPKC-nu;nPKCnu;nu;PKCnu;PKD 3;PKD3;PRK D3;PRKCN;PRKD 3;Prkd3;Protein kinase C;Protein kinase C nu;Protein kinase C nu type;Protein kinase D3;Protein kinase EPK 2;Protein kinase EPK2;Serine threonine protein kinase;Serine/threonine protein kinase D3;Serine/threonine-protein kinase D3;PKD1/2/3;KPCD1;Serine/threonine-protein kinas
Fields
>>Rap1 signaling pathway;>>Aldosterone synthesis and secretion;>>Chemical carcinogenesis - reactive oxygen species
人蛋白质序列数据库
Q15139/Q9BZL6/O94806
小鼠基因ID
18760/101540/75292
细胞定位
Cytoplasm . Cell membrane . Golgi apparatus, trans-Golgi network . Translocation to the cell membrane is required for kinase activation.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
