免疫原
The antiserum was produced against synthesized peptide derived from human LMTK2. AA range:651-700
特异性
KPI-2 Polyclonal Antibody detects endogenous levels of KPI-2 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates PPP1C, phosphorylase b and CFTR.,online information:LMTK2 entry,PTM:Autophosphorylated. Phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1C and inhibitor-2.,tissue specificity:Mainly expressed in skeletal muscle, and weakly in brain and pancreas.,
蛋白名称
Serine/threonine-protein kinase LMTK2
其他名称
AATYK 2;AATYK2;Apoptosis associated tyrosine kinase 2;Apoptosis-associated tyrosine kinase 2;Brain enriched kinase;Brain-enriched kinase;BREK;CDK5/p35 regulated kinase;CDK5/p35-regulated kinase;CPRK;cyclin-dependent kinase 5/p35-regulated kinase;FLJ46659;hBREK;KIAA179;Kinase phosphatase inhibitor 2;Kinase/phosphatase/inhibitor 2;KPI 2;KPI-2;KPI2;Lemur tyrosine kinase 2;LMR 2;LMR2;LMTK 2;Lmtk2;LMTK2_HUMAN;PPP1R1;protein phosphatase 1;regulatory subunit 1;Serine/threonine protein kinase KPI 2;Serine/threonine protein kinase KPI2;Serine/threonine protein kinase LMTK 2;Serine/threonine protein kinase LMTK2;Serine/threonine-protein kinase KPI-2;Serine/threonine-protein kinase LMTK2;KIAA1079
细胞定位
Membrane ; Multi-pass membrane protein .
组织表达
Mainly expressed in skeletal muscle, and weakly in brain and pancreas.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
