免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human FCGR2B/C. AA range:141-190
特异性
CD32-B/C Polyclonal Antibody detects endogenous levels of CD32-B/C protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
基因名称（Gene Name）
FCGR2B/FCGR2C
蛋白名称
Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c
其他名称
CD32;FCGR2B/FCGR2C;Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c;FCGR2B;FCG2;IGFR2;Low affinity immunoglobulin gamma Fc region receptor II-b;IgG Fc receptor II-b;CDw32;Fc-gamma RII-b;Fc-gamma-RIIb;FcRII-b;FCGR2C;Low affinity immunoglobulin gamma Fc region receptor II-c;IgG Fc receptor II-c;Fc-gamma RII-c;Fc-gamma-RIIc;FcRII-c
Fields
>>Phagosome;>>Osteoclast differentiation;>>B cell receptor signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Measles
细胞定位
Cell membrane; Single-pass type I membrane protein.
组织表达
Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
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