免疫原
Synthesized phosho peptide around human SAMHD1 (Thr592)
特异性
This antibody detects endogenous levels of Human Mouse Rat SAMHD1 (phospho-Thr592)
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1(SAMHD1) Homo sapiens This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010],
功能
function:May play a role in mediating proinflammatory responses to TNF-alpha signaling.,induction:By interferon gamma. Up-regulated in TNF-alpha treated lung fibroblasts.,similarity:Contains 1 HD domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,tissue specificity:Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.,
基因名称（Gene Name）
SAMHD1 MOP5
其他名称
CHBL2;DCIP;Dendritic cell derived IFNG induced protein;Dendritic cell-derived IFNG-induced protein;Deoxynucleoside triphosphate triphosphohydrolase SAMHD1;dNTPase;HD domain containing 1;HDDC1;Mg11;Monocyte protein 5;MOP 5;MOP-5;MOP5;OTTHUMP3889;SAM domain and HD domain 1;SAM domain and HD domain containing protein 1;SAM domain and HD domain-containing protein 1;SAMH1_HUMAN;Samhd1;SBBI88;SAMHD1 MOP5;SAMHD1 (Thr592);SAM domain and HD domain-containing protein 1 (EC 3.1.4.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5)
Fields
>>Viral life cycle - HIV-1;>>Human immunodeficiency virus 1 infection
细胞定位
Nucleus . Chromosome . Localizes to sites of DNA double-strand breaks in response to DNA damage. .
组织表达
Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes (PubMed:11064105). No expression is seen in brain and thymus (PubMed:11064105).
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