免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human PTGDR2. AA range:161-210
特异性
CD294 Polyclonal Antibody detects endogenous levels of CD294 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011],
功能
function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,
蛋白名称
Prostaglandin D2 receptor 2
其他名称
CD294;PTGDR2;Prostaglandin D2 receptor 2;CRTH2;DL1R;GPR44;Chemoattractant receptor-homologous molecule expressed on Th2 cells;G-protein coupled receptor 44
细胞定位
Cell membrane ; Multi-pass membrane protein . Internalized receptors colocalized with RAB11A. .
组织表达
Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils.
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