免疫原
The antiserum was produced against synthesized peptide derived from human GAP43 around the phosphorylation site of Ser41. AA range:8-57
特异性
Phospho-GAP-43 (S41) Polyclonal Antibody detects endogenous levels of GAP-43 protein only when phosphorylated at S41.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,
其他名称
Axonal membrane protein GAP 43;Axonal membrane protein GAP-43;B 5;Calmodulin binding protein P 57;F1;GAP 43;GAP43;Growth Associated Protein 43;Growth-associated protein 43;Nerve Growth Related Peptide;Nerve growth related peptide GAP43;NEUM_HUMAN;Neural phosphoprotein B 5;Neural phosphoprotein B-5;Neuromodulin;Neuron growth associated protein 43;PP46;Protein F1;QtrA-1158;QtrA-1371;GAP-43;Neural phosphoprotein B-50
细胞定位
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .
组织表达
Alzheimer cortex,Brain,Subthalamic nucleus,
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