免疫原
The antiserum was produced against synthesized peptide derived from human DARPP-32 around the phosphorylation site of Thr75. AA range:41-90
特异性
Phospho-DARPP-32 (T75) Polyclonal Antibody detects endogenous levels of DARPP-32 protein only when phosphorylated at T75.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
功能
function:Inhibitor of protein-phosphatase 1.,PTM:Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.,PTM:Phosphorylation of Thr-34 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family.,
蛋白名称
Protein phosphatase 1 regulatory subunit 1B
其他名称
DARPP 32;DARPP-32;Dopamine and cAMP regulated neuronal phosphoprotein 32;Dopamine and cAMP regulated neuronal phosphoprotein;Dopamine and cAMP regulated phosphoprotein;Dopamine and cAMP regulated phosphoprotein DARPP 32;Dopamine and cAMP regulated phosphoprotein DARPP32;Dopamine- and cAMP-regulated neuronal phosphoprotein;FLJ294;IPPD;Neuronal phosphoprotein DARPP 32;PPP1R1B;PPR1B_HUMAN;Protein phosphatase 1 regulatory (inhibitor) subunit 1B;Protein phosphatase 1 regulatory inhibitor subunit 1B;Protein phosphatase 1 regulatory subunit 1B;DARPP32
Fields
>>cAMP signaling pathway;>>Dopaminergic synapse;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism
组织表达
Adipose tissue,Brain,Cerebellum,Colon,Ovary,
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