免疫原
Synthesized peptide derived from human CEL3B AA range: 206-256
特异性
This antibody detects endogenous levels of CEL3B at Human/Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009],
基因名称（Gene Name）
CELA3B ELA3B
其他名称
Protease E;Elastase-3B;Elastase IIIB;EC:3.4.21.70;Chymotrypsin-like elastase family member 3B;CEL3B;CELA3B ELA3B
Fields
>>Pancreatic secretion;>>Protein digestion and absorption
细胞定位
extracellular space,
组织表达
Pancreas. Not detectable in keratinocytes.
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